EPIC-NOLA, our New Orleans based clinic, is a part of EPINET, a National Institute of Mental Health (NIMH) sponsored learning health care system for early psychosis. EPINET links over 100 early psychosis clinics across 17 states through standard clinical measures, data collection, data sharing and integration

Clear Answers to Louisiana’s Mental Health (CALM), our psychosis awareness campaign, is evidence-based and inspired by the success of social marketing campaigns in reducing the duration of untreated psychosis in Scandinavia (TIPS) and New Haven, CT (Mindmap).

Below are some relevant findings from the latest research on early psychosis psychosis education. The articles in bold are our own publications.


In Search of an Evidence-based Treatment to Reduce Duration of Untreated Psychosis

S. Chaudhry (Presenter), A. Weiss, S. Long, W. Atiya

This research poster was presented at the 2023 International Early Psychosis Association (IEPA) Early Intervention in Mental Health Conference. It covers how the CALM early detection campaign has increased awareness of psychosis and contributed to decreasing the duration of untreated psychosis.

Psychosis, Telehealth, and COVID-19: Engagement and Hospitalization Pre- and Peri-Pandemic

Serena Chaudhry, Robert Roy, Kasra Mansourian, Ashley Weiss, Alan Breier

This article explores the use of telehealth for individual psychotherapy and parts of medication management. It examines engagement and hospitalization rates with the different treatment modalities for first episode psychosis (FEP) care during an extended time period beyond the acute phase of the pandemic. Participants in this research are patients from the The Early Psychosis Intervention Clinic New Orleans (EPIC-NOLA).


Pathways to Care: How Help-Seeking Behaviors Relate to Duration of Untreated Psychosis and Treatment Engagement

Ashley Weiss, Spencer Steadman, Hannah D Mercier, Tonya Cross Hansel, Serena Chaudhry, Isabel Clark

The purpose of this project was to learn how individual help-seeking episodes (HSE), which includes things like hospitalization and seeking general counseling, affects an individual’s duration of untreated psychosis (DUP). We specifically looked at patients from Early Psychosis Intervention Clinic of New Orleans (EPIC-NOLA) and analyzed their pathways to care.

A systematic review of psychosis in social work literature

Serena Chaudhry, Robert Roy, Ashley Weiss, Tonya Hansel

This article highlights the poor visibility of psychosis in social work journals. Specifically information on the effectiveness of coordinated specialty care for psychosis. Poor visibility limits social work’s ability to provide individuals with the appropriate care or pathway to care.

A practice-oriented research initiative focused on developing a national early psychosis learning health care partnership

Robert K. Heinssen, and Susan T. Azrin

This article describes the development of national and regional health care partnerships such as the Recovery After an Initial Schizophrenia Episode (RAISE) initiative and Early Psychosis Intervention Network (EPINET). Future directions are explored as well.

Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial measured the effectiveness of a broad-based public awareness campaign in altering health outcomes

Vinod H Srihari, Maria Ferrara, Fangyong Li, Emily Kline, Sinan Gülöksüz, Jessica M Pollard, John D Cahill, Walter S Mathis, Laura Yoviene Sykes, Barbara C Walsh, Glen McDermott, Larry J Seidman, Deceased Ralitza Gueorguieva, Scott W Woods, Cenk Tek, Matcheri S Keshavan

This research explores if an early detection campaign can reduce the duration of untreated psychosis (DUP). The Mindmap campaign in this article was one of the inspirations for creating the CALM campaign.


Pathways to Care: How Help-Seeking Behaviors Relate to Duration of Untreated Psychosis and Treatment Engagement

Maria Ferrara, Sinan Guloksuz, Walter Mathis, Fangyong Li, I-Hsin Lin, Sumaiyah Syed, Keith Gallagher, Jai Shah, Emily Kline, Cenk Tek, Matcheri Keshavan, Vinod Srihari

This research compares individuals who sought help for psychosis upon first symptoms, to those who sought help after psychosis onset. It was concluded that early detection efforts that target prodromal samples may improve the length and experience of pathways to care.

The clinical significance of duration of untreated psychosis: an umbrella review and random-effects meta-analysis

Oliver D. Howes, Thomas Whitehurst, Ekaterina Shatalina, Leigh Townsend, Ellis Chika Onwordi, Tsz Lun Allenis Mak, Atheeshaan Arumuham, Oisín O’Brien, Maria Lobo, Luke Vano, Uzma Zahid, Emma Butler, Martin Osugo

This evidence suggests the relationships between duration of untreated psychosis (DUP) and positive symptoms, negative symptoms and chance of remission.

Capgras Syndrome: In the Conscious and the Unconscious Mind

Serena Chaudhry, Ashley Weiss, Costandino Surdis, Michael Garrett

This article covers Capgras syndrome, a syndrome characterized by a false belief that an identical duplicate has replaced someone significant to the patient. It raises questions about whether Capgras should be considered a stand-alone diagnosis or whether it should be placed within a wider spectrum of psychotic disorders.

Psychosis, Telehealth, and COVID-19: Successes and Lessons Learned From the First Wave of the Pandemic

Serena Chaudhry, Ashley Weiss, Grinasha Dillon, Ariana O’Shea, Tonya Cross Hansel

This research analyzed a first-episode psychosis (FEP) clinic’s shift from in-person treatment to telemental health treatment during COVID-19 pandemic. The feasibility of using this technology was examined by assessing client engagement.

Establishing the Early Psychosis Intervention Clinic, New Orleans (EPIC-NOLA): Sustainability Challenges Threaten Clinical Success

Ashley Weiss, Serena Chaudhry, John Danie Cahill, Vinod H Srihari

This paper describes the implementation of Early Psychosis Intervention Clinic-New Orleans (EPIC-NOLA), the first coordinated specialty care clinic for first episode psychosis in New Orleans, Louisiana, a historically underserved area. CALM is the psychosis awareness campaign for EPIC-NOLA.


Determinants of pathways to care among young adults with early psychosis entering a coordinated specialty care program

Leslie Marino, Jennifer Scodes, Hong Ngo, Ilana Nossel, Iruma Bello, Melanie Wall, Lisa Dixon

This research examines how various factors correlate with the duration of untreated psychosis (DUP), and to explore factors associated with time from onset of symptoms to first mental health service contact (help-seeking DUP).

Analysis of early intervention services on adult judicial outcomes

Jessica M. Pollard, Maria Ferrara, MD, I-Hsin Lin, Suat Kucukgoncu, Tobias Wasser, Fangyong Li, Vinod H. Srihari

This secondary analysis found that first-episode psychosis (FES) is associated with reduced criminality.


Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis

Christoph U. Correll, Britta Galling, Aditya Pawar, Anastasia Krivko, Chiara Bonetto, Mirella Ruggeri, Thomas J. Craig, Merete Nordentoft, Vinod H. Srihari, Sinan Guloksuz, Christy L. M. Hui, Eric Y. H. Chen, Marcelo Valencia, Francisco Juarez, Delbert G. Robinson, Nina R. Schooler, Mary F. Brunette, Kim T. Mueser, Robert A. Rosenheck, Patricia Marcy, Jean Addington, Sue E. Estroff, James Robinson, David Penn, Joanne B. Severe, John M. Kane

This research asks if early intervention services (EIS) are superior to treatment as usual regarding symptom-related and illness-related treatment outcomes in patients with early-phase psychosis? These results support the need for funding and use of EIS in patients with early-phase psychosis.

Can We Reduce the Duration of Untreated Psychosis? A Systematic Review and Meta-Analysis of Controlled Interventional Studies

Dominic Oliver, Cathy Davies, Georgia Crossland, Steffiany Lim, George Gifford, Philip McGuire, Paolo Fusar-Poli

This meta-analysis provides a significant quantitative summary of current evidence for interventions to reduce duration of untreated psychosis (DUP) during first episode psychosis (FEP). The findings show that more evidence is needed, but suggests that FEP services, community interventions, healthcare professional training, and multifocus interventions may be successful in reducing DUP.

About Early Psychosis Intervention Network (EPINET)

Early Psychosis Intervention Network (EPINET) is a broad research initiative established in order to determine the best way to treat people experiencing symptoms of early psychosis.